Diverse cellular functions, including inflammatory gene expression, DNA repair, and cell
proliferation, are regulated by histone acetylation. Transcriptional coactivators possess
intrinsic histone acetyltransferase activity, and this activity drives inflammatory gene
expression and the development of tolerance in macrophages. Eleven histone deacetylases
(HDACs) act to regulate the expression of distinct subsets of inflammatory/immune genes.
Other proteins, particularly transcription factors, are also acetylated and are targets for …