Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells
Y Yang, HM Haitchi, J Cakebread, D Sammut… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: A disintegrin and metalloprotease 33 (ADAM33) polymorphism is strongly
associated with asthma and bronchial hyperresponsiveness. Although considered to be a
mesenchymal cell–specific gene, recent reports have suggested epithelial expression of
ADAM33 in patients with severe asthma. OBJECTIVES: Because dysregulated expression of
ADAM33 can contribute to disease pathogenesis, we characterized the mechanism or
mechanisms that control its transcription and investigated ADAM33 expression in bronchial …
associated with asthma and bronchial hyperresponsiveness. Although considered to be a
mesenchymal cell–specific gene, recent reports have suggested epithelial expression of
ADAM33 in patients with severe asthma. OBJECTIVES: Because dysregulated expression of
ADAM33 can contribute to disease pathogenesis, we characterized the mechanism or
mechanisms that control its transcription and investigated ADAM33 expression in bronchial …