Opsonic activity of MCP-1 and MCP-2, cationic peptides from rabbit alveolar macrophages
J Fleischmann, ME Selsted, RI Lehrer - Diagnostic microbiology and …, 1985 - Elsevier
Abstract MCP-1 and MCP-2, cationic peptides derived from rabbit alveolar macrophages,
enhanced the ability of these cells to ingest Staphylococcus aureus, Klebsiella pneumoniae,
Bordetella bronchiseptica, and Candida albicans in vitro. The opsonic effect of MCP-1 was
potentiated by Ca++ and Mg++ and was associated with binding of the peptide to alveolar
macrophages and microorganisms. MCP-1 and MCP-2 may contribute to the ability of
alveolar macrophage to ingest microorganisms that gain entry to the lower respiratory tract.
enhanced the ability of these cells to ingest Staphylococcus aureus, Klebsiella pneumoniae,
Bordetella bronchiseptica, and Candida albicans in vitro. The opsonic effect of MCP-1 was
potentiated by Ca++ and Mg++ and was associated with binding of the peptide to alveolar
macrophages and microorganisms. MCP-1 and MCP-2 may contribute to the ability of
alveolar macrophage to ingest microorganisms that gain entry to the lower respiratory tract.