Association of the factor XII 46C> T polymorphism with risk of coronary heart disease (CHD) in the WOSCOPS study
F Zito, GDO Lowe, A Rumley, AD McMahon… - Atherosclerosis, 2002 - Elsevier
Aim: To evaluate the contribution of the 46C> T polymorphism of the Factor XII (FXII) gene to
risk for coronary heart disease (CHD) in the West of Scotland Coronary Prevention Study
(WOSCOPS) of men with high cholesterol. Background: WOSCOPS is a primary prevention
trial that demonstrated the effectiveness of pravastatin in reducing morbidity and mortality
from CHD. FXII is a protein of the contact system that plays a key role in both coagulation
and fibrinolysis. Elevated activated FXII (FXIIa) levels have been previously associated with …
risk for coronary heart disease (CHD) in the West of Scotland Coronary Prevention Study
(WOSCOPS) of men with high cholesterol. Background: WOSCOPS is a primary prevention
trial that demonstrated the effectiveness of pravastatin in reducing morbidity and mortality
from CHD. FXII is a protein of the contact system that plays a key role in both coagulation
and fibrinolysis. Elevated activated FXII (FXIIa) levels have been previously associated with …