Structural models of amyloid‐like fibrils

R Nelson, D Eisenberg - Advances in protein chemistry, 2006 - Elsevier
Amyloid fibrils are elongated, insoluble protein aggregates deposited in vivo in amyloid
diseases, and amyloid‐like fibrils are formed in vitro from soluble proteins. Both of these
groups of fibrils, despite differences in the sequence and native structure of their component
proteins, share common properties, including their core structure. Multiple models have
been proposed for the common core structure, but in most cases, atomic‐level structural
details have yet to be determined. Here we review several structural models proposed for …