Combination of MHC–peptide multimer-based T cell sorting with the Immunoscope permits sensitive ex vivo quantitation and follow-up of human CD8+ T cell immune …
A Lim, V Baron, L Ferradini, M Bonneville… - Journal of …, 2002 - Elsevier
Identification of MHC-restricted antigens and progress in the induction and control of
adaptive cytotoxic immune responses have led to renewed interest in immunotherapy as a
treatment for severe pathologies such as cancer and autoimmune diseases. Reliable
procedures for detecting and monitoring T cell responses induced by the treatment
throughout a clinical trial are needed in order to design rational protocols with increased
efficiency. We have attempted to develop such a procedure by combining T cell sorting …
adaptive cytotoxic immune responses have led to renewed interest in immunotherapy as a
treatment for severe pathologies such as cancer and autoimmune diseases. Reliable
procedures for detecting and monitoring T cell responses induced by the treatment
throughout a clinical trial are needed in order to design rational protocols with increased
efficiency. We have attempted to develop such a procedure by combining T cell sorting …