[HTML][HTML] Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
M Karbowniczek, T Cash, M Cheung… - Journal of Biological …, 2004 - ASBMB
Tuberous sclerosis complex (TSC) is a tumor suppressor gene syndrome with
manifestations that can include seizures, mental retardation, autism, and tumors in the brain,
retina, kidney, heart, and skin. The products of the TSC1 and TSC2 genes, hamartin and
tuberin, respectively, heterodimerize and inhibit the mammalian target of rapamycin (mTOR).
We found that tuberin expression increases p42/44 MAPK phosphorylation and B-Raf
kinase activity. Short interfering RNA down-regulation of tuberin decreased the p42/44 …
manifestations that can include seizures, mental retardation, autism, and tumors in the brain,
retina, kidney, heart, and skin. The products of the TSC1 and TSC2 genes, hamartin and
tuberin, respectively, heterodimerize and inhibit the mammalian target of rapamycin (mTOR).
We found that tuberin expression increases p42/44 MAPK phosphorylation and B-Raf
kinase activity. Short interfering RNA down-regulation of tuberin decreased the p42/44 …