[HTML][HTML] Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate …
AA Soyombo, SL Hofmann - Journal of Biological Chemistry, 1997 - ASBMB
Palmitoyl-protein thioesterase is a lysosomal hydrolase that removes long chain fatty acyl
groups from modified cysteine residues in proteins. Mutations in this enzyme were recently
shown to underlie the hereditary neurodegenerative disorder, infantile neuronal ceroid
lipofuscinosis, and lipid thioesters derived from acylated proteins were found to accumulate
in lymphoblasts from individuals with the disorder. In the current study, we describe the
cloning and expression of a second lysosomal thioesterase, palmitoyl-protein thioesterase 2 …
groups from modified cysteine residues in proteins. Mutations in this enzyme were recently
shown to underlie the hereditary neurodegenerative disorder, infantile neuronal ceroid
lipofuscinosis, and lipid thioesters derived from acylated proteins were found to accumulate
in lymphoblasts from individuals with the disorder. In the current study, we describe the
cloning and expression of a second lysosomal thioesterase, palmitoyl-protein thioesterase 2 …