Leukocyte transendothelial migration: orchestrating the underlying molecular machinery
RA Worthylake, K Burridge - Current opinion in cell biology, 2001 - Elsevier
RA Worthylake, K Burridge
Current opinion in cell biology, 2001•ElsevierTransendothelial migration of leukocytes involves the spatiotemporal regulation of adhesion
molecules, chemokines and cytoskeletal regulators. Recent results show that distinct steps
of leukocyte transendothelial migration are regulated by sequential integrin activation and
coordinated Rho family GTPase activity. Progress has been made in understanding how the
dynamic regulation of these molecules translates into leukocyte transmigration.
molecules, chemokines and cytoskeletal regulators. Recent results show that distinct steps
of leukocyte transendothelial migration are regulated by sequential integrin activation and
coordinated Rho family GTPase activity. Progress has been made in understanding how the
dynamic regulation of these molecules translates into leukocyte transmigration.
Transendothelial migration of leukocytes involves the spatiotemporal regulation of adhesion molecules, chemokines and cytoskeletal regulators. Recent results show that distinct steps of leukocyte transendothelial migration are regulated by sequential integrin activation and coordinated Rho family GTPase activity. Progress has been made in understanding how the dynamic regulation of these molecules translates into leukocyte transmigration.
Elsevier