Specific protein kinase C isoforms as transducers and modulators of insulin signaling
SR Sampson, DR Cooper - Molecular genetics and metabolism, 2006 - Elsevier
Recent studies implicate specific PKC isoforms in the insulin-signaling cascade. Insulin
activates PKCs α, βII, δ and ζ in several cell types. In addition, as will be documented in this
review, certain members of the PKC family may also be activated and act upstream of PI3
and MAP kinases. Each of these isoforms has been shown one way or another either to
mimic or to modify insulin-stimulated effects in one or all of the insulin-responsive tissues.
Moreover, each of the isoforms has been shown to be activated by insulin stimulation or …
activates PKCs α, βII, δ and ζ in several cell types. In addition, as will be documented in this
review, certain members of the PKC family may also be activated and act upstream of PI3
and MAP kinases. Each of these isoforms has been shown one way or another either to
mimic or to modify insulin-stimulated effects in one or all of the insulin-responsive tissues.
Moreover, each of the isoforms has been shown to be activated by insulin stimulation or …