γ/δT‐cell Subsets, NKG2A Expression and Apoptosis of Vδ2+ T cells in Pregnant Women with or without Risk of Premature Pregnancy Termination
L Szereday, A Barakonyi, E Miko… - American Journal of …, 2003 - Wiley Online Library
American Journal of Reproductive Immunology, 2003•Wiley Online Library
Problem: Potentially cytotoxic Vδ2+ T lymphocytes recognize human leukocyte antigen‐E on
the trophoblast via their CD94/NKG2A receptors. This study aims at determing the
percentage of γ/δ T‐cell subsets, their NKG2A and Annexin V positivity in peripheral blood of
healthy pregnant women and women at risk of premature pregnancy termination. Method of
Study: Peripheral Vδ2+ cells from healthy pregnant women and from women at risk of
premature pregnancy termination were tested for the KIR NKG2A and Annexin V positivity by …
the trophoblast via their CD94/NKG2A receptors. This study aims at determing the
percentage of γ/δ T‐cell subsets, their NKG2A and Annexin V positivity in peripheral blood of
healthy pregnant women and women at risk of premature pregnancy termination. Method of
Study: Peripheral Vδ2+ cells from healthy pregnant women and from women at risk of
premature pregnancy termination were tested for the KIR NKG2A and Annexin V positivity by …
Problem: Potentially cytotoxic Vδ2+ T lymphocytes recognize human leukocyte antigen‐E on the trophoblast via their CD94/NKG2A receptors. This study aims at determing the percentage of γ/δ T‐cell subsets, their NKG2A and Annexin V positivity in peripheral blood of healthy pregnant women and women at risk of premature pregnancy termination.
Method of Study: Peripheral Vδ2+ cells from healthy pregnant women and from women at risk of premature pregnancy termination were tested for the KIR NKG2A and Annexin V positivity by flow cytometry.
Results: The percentage of viable Vδ2+ T cells was higher, that of Vδ1+ T cells was lower in women at risk of premature pregnancy termination than in healthy pregnant women. The percentage of NKG2A+ Vδ2+ T cells was significantly lower in pregnant women at risk of premature pregnancy termination than in normal pregnancy.
Conclusions: These data suggest the involvement of γ/δ T lymphocytes in the pathogenesis of premature pregnancy termination.
Wiley Online Library