[HTML][HTML] MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2′, 3′-dideoxycytidine and 9 …
Y Guo, E Kotova, ZS Chen, K Lee… - Journal of Biological …, 2003 - ASBMB
MRP8 (ABCC11) is a recently identified cDNA that has been assigned to the multidrug
resistance-associated protein (MRP) family of ATP-binding cassette transporters, but its
functional characteristics have not been determined. Here we examine the functional
properties of the protein using transfected LLC-PK1 cells. It is shown that ectopic expression
of MRP8 reduces basal intracellular levels of cAMP and cGMP and enhances cellular
extrusion of cyclic nucleotides in the presence or absence of stimulation with forskolin or SIN …
resistance-associated protein (MRP) family of ATP-binding cassette transporters, but its
functional characteristics have not been determined. Here we examine the functional
properties of the protein using transfected LLC-PK1 cells. It is shown that ectopic expression
of MRP8 reduces basal intracellular levels of cAMP and cGMP and enhances cellular
extrusion of cyclic nucleotides in the presence or absence of stimulation with forskolin or SIN …