[HTML][HTML] Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors
M Higuchi, M Tomioka, J Takano, K Shirotani… - Journal of Biological …, 2005 - ASBMB
Enzymatic proteolysis has been implicated in diverse neuropathological conditions,
including acute/subacute ischemic brain injuries and chronic neurodegeneration such as
Alzheimer disease and Parkinson disease. Calcium-dependent proteases, calpains, have
been intensively analyzed in relation to these pathological conditions, but in vivo
experiments have been hampered by the lack of appropriate experimental systems for a
selective regulation of the calpain activity in animals. Here we have generated transgenic …
including acute/subacute ischemic brain injuries and chronic neurodegeneration such as
Alzheimer disease and Parkinson disease. Calcium-dependent proteases, calpains, have
been intensively analyzed in relation to these pathological conditions, but in vivo
experiments have been hampered by the lack of appropriate experimental systems for a
selective regulation of the calpain activity in animals. Here we have generated transgenic …