[HTML][HTML] Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent …
C Mbebi, V Sée, L Mercken, L Pradier, U Müller… - Journal of Biological …, 2002 - ASBMB
The aberrant metabolism of β-amyloid precursor protein (APP) and the progressive
deposition of its derived fragment β-amyloid peptide are early and constant pathological
hallmarks of Alzheimer's disease. Because APP is able to function as a cell surface receptor,
we investigated here whether a disruption of the normal function of APP may contribute to
the pathogenic mechanisms in Alzheimer's disease. To this aim, we generated a specific
chicken polyclonal antibody directed against the extracellular domain of APP, which is …
deposition of its derived fragment β-amyloid peptide are early and constant pathological
hallmarks of Alzheimer's disease. Because APP is able to function as a cell surface receptor,
we investigated here whether a disruption of the normal function of APP may contribute to
the pathogenic mechanisms in Alzheimer's disease. To this aim, we generated a specific
chicken polyclonal antibody directed against the extracellular domain of APP, which is …