[HTML][HTML] Calpain inhibitor I increases β-amyloid peptide production by inhibiting the degradation of the substrate of γ-secretase: evidence that substrate availability …
L Zhang, L Song, EM Parker - Journal of Biological Chemistry, 1999 - ASBMB
The calpain inhibitorN-acetyl-leucyl-leucyl-norleucinal (ALLN) has been reported to have
complex effects on the production of the β-amyloid peptide (Aβ). In this study, the effects of
ALLN on the processing of the amyloid precursor protein (APP) to Aβ were examined in 293
cells expressing APP or the C-terminal 100 amino acids of APP (C100). In cells expressing
APP or low levels of C100, ALLN increased Aβ40 and Aβ42 secretion at low concentrations,
decreased Aβ40 and Aβ42 secretion at high concentrations, and increased cellular levels of …
complex effects on the production of the β-amyloid peptide (Aβ). In this study, the effects of
ALLN on the processing of the amyloid precursor protein (APP) to Aβ were examined in 293
cells expressing APP or the C-terminal 100 amino acids of APP (C100). In cells expressing
APP or low levels of C100, ALLN increased Aβ40 and Aβ42 secretion at low concentrations,
decreased Aβ40 and Aβ42 secretion at high concentrations, and increased cellular levels of …