[HTML][HTML] Apolipoprotein AI mimetic peptide helix number and helix linker influence potentially anti-atherogenic properties
GD Wool, CA Reardon, GS Getz - Journal of lipid research, 2008 - ASBMB
We hypothesize that apolipoprotein AI (apoA-I) mimetic peptides better mimicking the
punctuated α-helical repeats of full-length apoA-I are more anti-inflammatory and anti-
atherogenic. This study compares a monomeric apoA-I mimetic helix to three different
tandem helix peptides in vitro: 4F (18 mer), 4F-proline-4F (37 mer, Pro), 4F-alanine-4F (37
mer, Ala), and 4F-KVEPLRA-4F [the human apoA-I 4/5 interhelical sequence (IHS), 43 mer].
All peptides cleared turbid lipid suspensions, with 4F being most effective. In contrast to lipid …
punctuated α-helical repeats of full-length apoA-I are more anti-inflammatory and anti-
atherogenic. This study compares a monomeric apoA-I mimetic helix to three different
tandem helix peptides in vitro: 4F (18 mer), 4F-proline-4F (37 mer, Pro), 4F-alanine-4F (37
mer, Ala), and 4F-KVEPLRA-4F [the human apoA-I 4/5 interhelical sequence (IHS), 43 mer].
All peptides cleared turbid lipid suspensions, with 4F being most effective. In contrast to lipid …