[HTML][HTML] Metabolic adaptations in the absence of perilipin: increased β-oxidation and decreased hepatic glucose production associated with peripheral insulin …
PK Saha, H Kojima, J Martinez-Botas… - Journal of Biological …, 2004 - ASBMB
Targeted disruption of the lipid droplet protein, perilipin, in mice leads to constitutional
lipolysis associated with marked reduction in white adipose tissue as a result of unbridled
lipolysis. To investigate the metabolic adaptations in response to the constitutive lipolysis,
we studied perilipin-null (plin–/–) mice in terms of their fatty acid oxidation and glycerol and
glucose metabolism homeostasis by using dynamic biochemical testing and clamp and
tracer infusion methods. plin–/–mice showed increased β-oxidation in muscle, liver, and …
lipolysis associated with marked reduction in white adipose tissue as a result of unbridled
lipolysis. To investigate the metabolic adaptations in response to the constitutive lipolysis,
we studied perilipin-null (plin–/–) mice in terms of their fatty acid oxidation and glycerol and
glucose metabolism homeostasis by using dynamic biochemical testing and clamp and
tracer infusion methods. plin–/–mice showed increased β-oxidation in muscle, liver, and …