Marijuana and tobacco smoke gas-phase cytotoxins
GL Huber, MW First, O Grubner - Pharmacology Biochemistry and Behavior, 1991 - Elsevier
To evaluate the in vivo versus in vitro paradoxical effects of marijuana and tobacco smoke
on pulmonary defenses, the responses to smoke constituents were assessed with an
alveolar macrophage tissue culture bioassay. A dose-response impairment of macrophage
bactericidal activity was associated with water-soluble, gas-phase constituents. A model
airway surface was constructed to examine the behavior of specific gas-phase constituents
removed as they passed over wetted surfaces simulating the characteristics of the human …
on pulmonary defenses, the responses to smoke constituents were assessed with an
alveolar macrophage tissue culture bioassay. A dose-response impairment of macrophage
bactericidal activity was associated with water-soluble, gas-phase constituents. A model
airway surface was constructed to examine the behavior of specific gas-phase constituents
removed as they passed over wetted surfaces simulating the characteristics of the human …