Inhibitors of protein biosynthesis: II. Mode of action of anisomycin
AP Grollman - Journal of Biological Chemistry, 1967 - ASBMB
Anisomycin (2-p-methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine) inhibits protein
synthesis in HeLa cells, rabbit reticulocytes, Saccharomyces fragilis, and cell-free extracts
prepared from these sources, but it is inactive against extracts of Escherichia coli. Partial
inhibition of deoxyribonucleic acid synthesis in HeLa cells is observed at anisomycin
concentrations which produce 95% inhibition of protein synthesis. These effects on protein
and DNA synthesis are rapid in onset and reversible. Anisomycin acts on the transfer …
synthesis in HeLa cells, rabbit reticulocytes, Saccharomyces fragilis, and cell-free extracts
prepared from these sources, but it is inactive against extracts of Escherichia coli. Partial
inhibition of deoxyribonucleic acid synthesis in HeLa cells is observed at anisomycin
concentrations which produce 95% inhibition of protein synthesis. These effects on protein
and DNA synthesis are rapid in onset and reversible. Anisomycin acts on the transfer …