Cytotoxic Flavaglines and Bisamides from Aglaia edulis
Journal of natural products, 2006•ACS Publications
Two new cyclopenta [b] benzofurans, aglaroxin A 1-O-acetate (2) and 3 '-methoxyaglaroxin
A 1-O-acetate (3), a new benzo [b] oxepine, 19, 20-dehydroedulisone A (4), and five new
cyclopenta [bc] benzopyrans, edulirin A (5), edulirin A 10-O-acetate (6), 19, 20-
dehydroedulirin A (7), isoedulirin A (8), and edulirin B (9), were isolated from the bark of
Aglaia edulis, along with one known cyclopenta [b] benzofuran, aglaroxin A (1). Additionally,
four new amides, aglamides A− D (10− 13), as well as three known compounds …
A 1-O-acetate (3), a new benzo [b] oxepine, 19, 20-dehydroedulisone A (4), and five new
cyclopenta [bc] benzopyrans, edulirin A (5), edulirin A 10-O-acetate (6), 19, 20-
dehydroedulirin A (7), isoedulirin A (8), and edulirin B (9), were isolated from the bark of
Aglaia edulis, along with one known cyclopenta [b] benzofuran, aglaroxin A (1). Additionally,
four new amides, aglamides A− D (10− 13), as well as three known compounds …
Two new cyclopenta[b]benzofurans, aglaroxin A 1-O-acetate (2) and 3‘-methoxyaglaroxin A 1-O-acetate (3), a new benzo[b]oxepine, 19,20-dehydroedulisone A (4), and five new cyclopenta[bc]benzopyrans, edulirin A (5), edulirin A 10-O-acetate (6), 19,20-dehydroedulirin A (7), isoedulirin A (8), and edulirin B (9), were isolated from the bark of Aglaia edulis, along with one known cyclopenta[b]benzofuran, aglaroxin A (1). Additionally, four new amides, aglamides A−D (10−13), as well as three known compounds, aglalactone, scopoletin, and 5-hydroxy-3,6,7,4‘-tetramethoxyflavone, were isolated from the leaves and/or twigs of this species. The structures of the new compounds (2−13) were elucidated by interpretation of their spectroscopic data. All isolates obtained in this study were evaluated for cytotoxicity against both several human cancer cell lines (Lu1, LNCaP, and MCF-7) and a nontumorigenic (HUVEC) cell line. Among these isolates, the cyclopenta[b]benzofurans (1−3) exhibited potent in vitro cytotoxic activity (ED50 range 0.001 to 0.8 μg/mL). Aglaroxin A 1-O-acetate (2) was further evaluated in the in vivo P388 lymphocytic leukemia model, by intraperitoneal injection, but found to be inactive in this model.
ACS Publications