[HTML][HTML] Pancreatic acinar cells express vesicle-associated membrane protein 2-and 8-specific populations of zymogen granules with distinct and overlapping roles in …
N Weng, DDH Thomas, GE Groblewski - Journal of biological chemistry, 2007 - ASBMB
Previous studies have demonstrated roles for vesicle-associated membrane protein 2
(VAMP 2) and VAMP 8 in Ca 2+-regulated pancreatic acinar cell secretion, however, their
coordinated function in the secretory pathway has not been addressed. Here we provide
evidence using immunofluorescence microscopy, cell fractionation, and SNARE protein
interaction studies that acinar cells contain two distinct populations of zymogen granules
(ZGs) expressing either VAMP 2 or VAMP 8. Further, VAMP 8-positive granules also contain …
(VAMP 2) and VAMP 8 in Ca 2+-regulated pancreatic acinar cell secretion, however, their
coordinated function in the secretory pathway has not been addressed. Here we provide
evidence using immunofluorescence microscopy, cell fractionation, and SNARE protein
interaction studies that acinar cells contain two distinct populations of zymogen granules
(ZGs) expressing either VAMP 2 or VAMP 8. Further, VAMP 8-positive granules also contain …