[HTML][HTML] Impaired pressure sensation in mice lacking TRPV4
M Suzuki, A Mizuno, K Kodaira, M Imai - Journal of Biological Chemistry, 2003 - ASBMB
The sensation of pressure, mechanosensation, in vertebrates remains poorly understood on
the molecular level. The ion channel TRPV4 is in the TRP family and is a candidate for a
mechanosensitive calcium-permeable channel. It is located in dorsal root ganglia. In the
present study, we show that disrupting the Trpv4 gene in mice markedly reduced the
sensitivity of the tail to pressure and acidic nociception. The threshold to noxious stimuli and
the conduction velocity of myelinated nerve responding to stimuli were also impaired …
the molecular level. The ion channel TRPV4 is in the TRP family and is a candidate for a
mechanosensitive calcium-permeable channel. It is located in dorsal root ganglia. In the
present study, we show that disrupting the Trpv4 gene in mice markedly reduced the
sensitivity of the tail to pressure and acidic nociception. The threshold to noxious stimuli and
the conduction velocity of myelinated nerve responding to stimuli were also impaired …