The pathogenesis of hemangiomas: a review

CG Bauland, MAM van Steensel… - Plastic and …, 2006 - journals.lww.com
CG Bauland, MAM van Steensel, PM Steijlen, PNMA Rieu, PHM Spauwen
Plastic and reconstructive surgery, 2006journals.lww.com
Background: Hemangiomas of infancy are common endothelial tumors. They differ from
vascular malformations in their tissue architecture and biological properties. To date, there is
no universally accepted theory that explains the pathogenesis and pathophysiology of
hemangiomas. Methods: Theories from the medical literature from 1981 to 2004 were
gathered, categorized, and reviewed. Results: Current research is mostly on the cellular and
genetic levels. The most authoritative theories focus on angioblast origins, trophoblast …
Background:
Hemangiomas of infancy are common endothelial tumors. They differ from vascular malformations in their tissue architecture and biological properties. To date, there is no universally accepted theory that explains the pathogenesis and pathophysiology of hemangiomas.
Methods:
Theories from the medical literature from 1981 to 2004 were gathered, categorized, and reviewed.
Results:
Current research is mostly on the cellular and genetic levels. The most authoritative theories focus on angioblast origins, trophoblast origins, mutations in cytokine regulatory pathways, and field defects as the cause of the deranged angiogenesis of hemangiomas.
Conclusions:
To date, no single theory can easily explain all the characteristics of hemangiomas, such as predilection for the female sex, usual occurrence after birth, spontaneous involution, abnormal tissue architecture, and distribution within a developmental field. Hemangiomas are probably the final common expression of several pathophysiological mechanisms taking effect alone or in combination.
Lippincott Williams & Wilkins