[HTML][HTML] Epidermal growth factor receptor (EGFR) antibody down-regulates mutant receptors and inhibits tumors expressing EGFR mutations
M Perez-Torres, M Guix, A Gonzalez… - Journal of biological …, 2006 - ASBMB
Activating mutations in the kinase domain of the EGF receptor have been reported in non-
small cell lung cancer. The majority of tumors expressing these mutants are sensitive to ATP
mimetics that inhibit the EGFR tyrosine kinase. The effect of antibodies that bind to the
ectodomain of the receptor is less clear. We report herein the effects and mechanisms of
action of the antibody cetuximab in lung cancer cells that naturally express receptor
mutations and in ErbB-null 32D hematopoietic cells transfected with mutant EGFR …
small cell lung cancer. The majority of tumors expressing these mutants are sensitive to ATP
mimetics that inhibit the EGFR tyrosine kinase. The effect of antibodies that bind to the
ectodomain of the receptor is less clear. We report herein the effects and mechanisms of
action of the antibody cetuximab in lung cancer cells that naturally express receptor
mutations and in ErbB-null 32D hematopoietic cells transfected with mutant EGFR …