The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages
Y Fu, N Luo, MF Lopes-Virella, WT Garvey - Atherosclerosis, 2002 - Elsevier
The critical initiating event in atherogenesis involves the invasion of monocytes through the
endothelial wall of arteries, and their transformation from macrophages into foam cells.
Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol
myristate acetate (PMA) treatment, and can then be converted into foam cells by exposure to
oxidized low-density lipoprotein (oxLDL). To define genes that are specifically expressed
during the transformation of macrophages into foam cells, we have performed a subtractive …
endothelial wall of arteries, and their transformation from macrophages into foam cells.
Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol
myristate acetate (PMA) treatment, and can then be converted into foam cells by exposure to
oxidized low-density lipoprotein (oxLDL). To define genes that are specifically expressed
during the transformation of macrophages into foam cells, we have performed a subtractive …