Selective localization of cardiac SCN5A sodium channels in limbic regions of rat brain
HA Hartmann, LV Colom, ML Sutherland… - Nature …, 1999 - nature.com
HA Hartmann, LV Colom, ML Sutherland, JL Noebels
Nature neuroscience, 1999•nature.comVoltage-dependent sodium channels have a critical role in membrane electrogenesis and
repetitive firing in excitable cells. Members of this gene superfamily exhibit diffuse, tissue-
specific expression in nervous, muscle and cardiac tissues 1. Tetrodotoxin (TTX) sensitivity
and resistance to zinc blockade were thought to distinguish brain from heart sodium
channels, but neuronal Na+ currents with heart-like properties have been found in brain 2.
repetitive firing in excitable cells. Members of this gene superfamily exhibit diffuse, tissue-
specific expression in nervous, muscle and cardiac tissues 1. Tetrodotoxin (TTX) sensitivity
and resistance to zinc blockade were thought to distinguish brain from heart sodium
channels, but neuronal Na+ currents with heart-like properties have been found in brain 2.
Abstract
Voltage-dependent sodium channels have a critical role in membrane electrogenesis and repetitive firing in excitable cells. Members of this gene superfamily exhibit diffuse, tissue-specific expression in nervous, muscle and cardiac tissues 1. Tetrodotoxin (TTX) sensitivity and resistance to zinc blockade were thought to distinguish brain from heart sodium channels, but neuronal Na+ currents with heart-like properties have been found in brain 2.
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