Effects of ryanodine receptor activation on neurotransmitter release and neuronal cell death following kainic acid-induced status epilepticus
F Mori, M Okada, M Tomiyama, S Kaneko… - Epilepsy research, 2005 - Elsevier
Dynamic changes in intracellular free Ca2+ concentration play a crucial role in various
neural functions. The inositol 1, 4, 5-trisphosphate (IP3) receptor (IP3R) and the ryanodine
(Ry) receptor (RyR) are involved in Ca2+-induced Ca2+-release (CICR). Recent studies
have shown that type 3 IP3R is highly expressed in rat hippocampal neurons after kainic
acid (KA)-induced seizures and that dantrolene, a RyR antagonist, reduces KA-induced
neuronal cell death. We investigated the RyR-associated effects of CICR agents on basal …
neural functions. The inositol 1, 4, 5-trisphosphate (IP3) receptor (IP3R) and the ryanodine
(Ry) receptor (RyR) are involved in Ca2+-induced Ca2+-release (CICR). Recent studies
have shown that type 3 IP3R is highly expressed in rat hippocampal neurons after kainic
acid (KA)-induced seizures and that dantrolene, a RyR antagonist, reduces KA-induced
neuronal cell death. We investigated the RyR-associated effects of CICR agents on basal …