[HTML][HTML] β Subunits of voltage-gated sodium channels are novel substrates of β-site amyloid precursor protein-cleaving enzyme (BACE1) and γ-secretase
HK Wong, T Sakurai, F Oyama, K Kaneko… - Journal of Biological …, 2005 - ASBMB
Sequential processing of amyloid precursor protein (APP) by membrane-bound proteases,
BACE1 and γ-secretase, plays a crucial role in the pathogenesis of Alzheimer disease.
Much has been discovered on the properties of these proteases; however, regulatory
mechanisms of enzyme-substrate interaction in neurons and their involvement in
pathological changes are still not fully understood. It is mainly because of the membrane-
associated cleavage of these proteases and the lack of information on new substrates …
BACE1 and γ-secretase, plays a crucial role in the pathogenesis of Alzheimer disease.
Much has been discovered on the properties of these proteases; however, regulatory
mechanisms of enzyme-substrate interaction in neurons and their involvement in
pathological changes are still not fully understood. It is mainly because of the membrane-
associated cleavage of these proteases and the lack of information on new substrates …