[HTML][HTML] The extracellular domain of the β1 subunit is both necessary and sufficient for β1-like modulation of sodium channel gating
KA McCormick, J Srinivasan, K White, T Scheuer… - Journal of Biological …, 1999 - ASBMB
The type IIA voltage-gated sodium Na+ channel from rat brain is composed of a large, pore-
forming α subunit and the auxiliary subunits β1 and β2. When expressed in Xenopus
oocytes, the β1 subunit modulates the gating properties of the type IIA α subunit, resulting in
acceleration of both inactivation and recovery from inactivation and in a negative shift in the
voltage dependence of fast inactivation. The β1 subunit is composed of an extracellular
domain with a single immunoglobulin-like fold, a single transmembrane segment, and a …
forming α subunit and the auxiliary subunits β1 and β2. When expressed in Xenopus
oocytes, the β1 subunit modulates the gating properties of the type IIA α subunit, resulting in
acceleration of both inactivation and recovery from inactivation and in a negative shift in the
voltage dependence of fast inactivation. The β1 subunit is composed of an extracellular
domain with a single immunoglobulin-like fold, a single transmembrane segment, and a …