[HTML][HTML] c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2
C Jacob, GS Cottrell, D Gehringer, F Schmidlin… - Journal of Biological …, 2005 - ASBMB
Mechanisms that arrest G-protein-coupled receptor (GPCR) signaling prevent uncontrolled
stimulation that could cause disease. Although uncoupling from heterotrimeric G-proteins,
which transiently arrests signaling, is well described, little is known about the mechanisms
that permanently arrest signaling. Here we reported on the mechanisms that terminate
signaling by protease-activated receptor 2 (PAR 2), which mediated the proinflammatory
and nociceptive actions of proteases. Given its irreversible mechanism of proteolytic …
stimulation that could cause disease. Although uncoupling from heterotrimeric G-proteins,
which transiently arrests signaling, is well described, little is known about the mechanisms
that permanently arrest signaling. Here we reported on the mechanisms that terminate
signaling by protease-activated receptor 2 (PAR 2), which mediated the proinflammatory
and nociceptive actions of proteases. Given its irreversible mechanism of proteolytic …