[HTML][HTML] Intracellular Na+ regulates dopamine and angiotensin II receptors availability at the plasma membrane and their cellular responses in renal epithelia
R Efendiev, CE Budu, AR Cinelli, AM Bertorello… - Journal of Biological …, 2003 - ASBMB
The balance and cross-talk between natruretic and antinatruretic hormone receptors plays a
critical role in the regulation of renal Na+ homeostasis, which is a major determinant of
blood pressure. Dopamine and angiotensin II have antagonistic effects on renal Na+ and
water excretion, which involves regulation of the Na+, K+-ATPase activity. Herein we
demonstrate that angiotensin II (Ang II) stimulation of AT1 receptors in proximal tubule cells
induces the recruitment of Na+, K+-ATPase molecules to the plasmalemma, in a process …
critical role in the regulation of renal Na+ homeostasis, which is a major determinant of
blood pressure. Dopamine and angiotensin II have antagonistic effects on renal Na+ and
water excretion, which involves regulation of the Na+, K+-ATPase activity. Herein we
demonstrate that angiotensin II (Ang II) stimulation of AT1 receptors in proximal tubule cells
induces the recruitment of Na+, K+-ATPase molecules to the plasmalemma, in a process …