[HTML][HTML] Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src
H He, VJ Venema, X Gu, RC Venema… - Journal of Biological …, 1999 - ASBMB
Vascular endothelial growth factor (VEGF) is a potent endothelial cell-specific mitogen that
promotes angiogenesis, vascular hyperpermeability, and vasodilation by autocrine
mechanisms involving nitric oxide (NO) and prostacyclin (PGI 2) production. These
experiments used immunoprecipitation and immunoassay procedures to characterize the
signaling pathways by which VEGF induces NO and PGI 2 formation in cultured endothelial
cells. The data showed that VEGF stimulates complex formation of the flk-1/kinase-insert …
promotes angiogenesis, vascular hyperpermeability, and vasodilation by autocrine
mechanisms involving nitric oxide (NO) and prostacyclin (PGI 2) production. These
experiments used immunoprecipitation and immunoassay procedures to characterize the
signaling pathways by which VEGF induces NO and PGI 2 formation in cultured endothelial
cells. The data showed that VEGF stimulates complex formation of the flk-1/kinase-insert …