Effect of chronic nicotine administration on trinitrobenzene sulphonic acid-induced colitis
R Eliakim, F Karmeli, D Rachmilewitz… - European journal of …, 1998 - journals.lww.com
Background: Smoking, probably due to nicotine, has a bivalent effect on inflammatory bowel
disease, ameliorating disease activity in ulcerative colitis and with a deleterious effect on
Crohn's disease. The effect of nicotine patches in ulcerative colitis is controversial. Aim: To
investigate the effect of chronic nicotine use in a rat model of colitis. Methods: Colitis was
induced in Sprague-Dawley rats by rectal administration of 30 mg trinitrobenzene sulphonic
acid (TNBS) in 50% ethanol. Nicotine was dissolved in drinking water (2.5, 12.5, 25 and 250 …
disease, ameliorating disease activity in ulcerative colitis and with a deleterious effect on
Crohn's disease. The effect of nicotine patches in ulcerative colitis is controversial. Aim: To
investigate the effect of chronic nicotine use in a rat model of colitis. Methods: Colitis was
induced in Sprague-Dawley rats by rectal administration of 30 mg trinitrobenzene sulphonic
acid (TNBS) in 50% ethanol. Nicotine was dissolved in drinking water (2.5, 12.5, 25 and 250 …