Protective role of vagal afferents in experimentally-induced colitis in rats
L Mazelin, V Theodorou, J More, J Fioramonti… - Journal of the autonomic …, 1998 - Elsevier
The aim of this study was to evaluate the regulatory role of vagal afferents in the
development of colonic inflammation induced by trinitrobenzenesulfonic acid (TNBS) in rats.
Groups of Wistar rats were treated with capsaicin or its vehicle applied perivagally (sham
treatment). Colonic transit time was evaluated, and, two days later, one half of the animals
received an intracolonic instillation of TNBS/ethanol (40 mg/kg), and the other received
saline. Inflammation was evaluated functionally (gut permeability), biochemically …
development of colonic inflammation induced by trinitrobenzenesulfonic acid (TNBS) in rats.
Groups of Wistar rats were treated with capsaicin or its vehicle applied perivagally (sham
treatment). Colonic transit time was evaluated, and, two days later, one half of the animals
received an intracolonic instillation of TNBS/ethanol (40 mg/kg), and the other received
saline. Inflammation was evaluated functionally (gut permeability), biochemically …