[HTML][HTML] Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice
CF Semenkovich, T Coleman, A Daugherty - Journal of lipid research, 1998 - ASBMB
Heterozygous lipoprotein lipase defi ciency (LPL+/-) is common and has been implicated in
premature atherosclerosis in epidemiologic studies. However, in vitro data suggest that LPL
deficiency in the vascular wall may be antiatherogenic. To address the role of LPL in
atherosclerosis, LPL+/-mice in the C57BL/6J background were fed an atherogenic diet for 8
months. LPL+/-mice were more dyslipidemic than+/+ animals due to increased
concentrations of non-HDL lipoproteins. There was no difference in aortic origin …
premature atherosclerosis in epidemiologic studies. However, in vitro data suggest that LPL
deficiency in the vascular wall may be antiatherogenic. To address the role of LPL in
atherosclerosis, LPL+/-mice in the C57BL/6J background were fed an atherogenic diet for 8
months. LPL+/-mice were more dyslipidemic than+/+ animals due to increased
concentrations of non-HDL lipoproteins. There was no difference in aortic origin …