[HTML][HTML] 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
X Fu, JG Menke, Y Chen, G Zhou, KL MacNaul… - Journal of Biological …, 2001 - ASBMB
The nuclear receptors liver X receptor α (LXRα)(NR1H3) and LXRβ (NR1H2) are important
regulators of genes involved in lipid metabolism, including ABCA1, ABCG1, and sterol
regulatory element-binding protein-1c (SREBP-1c). Although it has been demonstrated that
oxysterols are LXR ligands, little is known about the identity of the physiological activators of
these receptors. Here we confirm earlier studies demonstrating a dose-dependent induction
of ABCA1 and ABCG1 in human monocyte-derived macrophages by cholesterol loading. In …
regulators of genes involved in lipid metabolism, including ABCA1, ABCG1, and sterol
regulatory element-binding protein-1c (SREBP-1c). Although it has been demonstrated that
oxysterols are LXR ligands, little is known about the identity of the physiological activators of
these receptors. Here we confirm earlier studies demonstrating a dose-dependent induction
of ABCA1 and ABCG1 in human monocyte-derived macrophages by cholesterol loading. In …