[HTML][HTML] Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes
M Funamoto, Y Fujio, K Kunisada, S Negoro… - Journal of Biological …, 2000 - ASBMB
Activation of glycoprotein (gp) 130 transduces hypertrophic and cytoprotective signals in
cardiac myocytes. In the present study, we have demonstrated that signals through gp130
increase the expression of vascular endothelial growth factor (VEGF) in cardiac myocytes
via the signal transducer and activator of transcription (STAT) 3 pathway. After activation of
gp130 with leukemia inhibitory factor (LIF), expression of VEGF mRNA rapidly increased
with a peak at 3 h in cultured cardiac myocytes. Cardiotrophin-1 also enhanced VEGF …
cardiac myocytes. In the present study, we have demonstrated that signals through gp130
increase the expression of vascular endothelial growth factor (VEGF) in cardiac myocytes
via the signal transducer and activator of transcription (STAT) 3 pathway. After activation of
gp130 with leukemia inhibitory factor (LIF), expression of VEGF mRNA rapidly increased
with a peak at 3 h in cultured cardiac myocytes. Cardiotrophin-1 also enhanced VEGF …