[HTML][HTML] CCAAT/enhancer-binding protein-α cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding
TE Harris, JH Albrecht, M Nakanishi… - Journal of Biological …, 2001 - ASBMB
CCAAT/enhancer-binding protein-α (C/EBPα) is a basic leucine zipper protein that controls
transcription of genes important for liver function, white adipose tissue development, and
granulocyte differentiation. In addition to its function in controlling gene expression in
differentiated tissues, C/EBPα is also associated with an antimitotic activity. We have
previously demonstrated that C/EBPα interacts with p21, a cyclin-dependent kinase (CDK)
inhibitor, and that C/EBPα inhibits proliferation when expressed in several different cell types …
transcription of genes important for liver function, white adipose tissue development, and
granulocyte differentiation. In addition to its function in controlling gene expression in
differentiated tissues, C/EBPα is also associated with an antimitotic activity. We have
previously demonstrated that C/EBPα interacts with p21, a cyclin-dependent kinase (CDK)
inhibitor, and that C/EBPα inhibits proliferation when expressed in several different cell types …