Enhancing the effect of THERATOPE STn-KLH cancer vaccine in patients with metastatic breast cancer by pretreatment with low-dose intravenous cyclophosphamide
GD MacLean, DW Miles, RD Rubens… - Journal of …, 1996 - journals.lww.com
THERATOPE (Biomira Inc., Edmonton, AB, Canada) STn-KLH cancer vaccine induces
strong antibody titers against both the synthetic STn epitope and against a natural mucin,
OSM, which expresses STn-like epitopes. In prospective, randomized studies in patients
with metastatic breast cancer treated at two cancer centers, the effect of different low-dose,
immunomodulatory cyclophosphamide (cyclo) pretreatments on the response to
THERATOPE STn-KLH was compared. Patients were randomized to receive either …
strong antibody titers against both the synthetic STn epitope and against a natural mucin,
OSM, which expresses STn-like epitopes. In prospective, randomized studies in patients
with metastatic breast cancer treated at two cancer centers, the effect of different low-dose,
immunomodulatory cyclophosphamide (cyclo) pretreatments on the response to
THERATOPE STn-KLH was compared. Patients were randomized to receive either …