Prefrontal electrophysiologic “noise” and catechol-O-methyltransferase genotype in schizophrenia
G Winterer, MF Egan, BS Kolachana, TE Goldberg… - Biological …, 2006 - Elsevier
BACKGROUND: Increased variability of stimulus-induced prefrontal electromagnetic activity
(“noise”) has been associated with genetic risk for schizophrenia. On the basis of animal
experiments and computational models, we have predicted that this prefrontal “noise”
phenotype would be related to variation in prefrontal dopamine (DA) signaling, which itself
might be abnormal in schizophrenia. In the present study, the effect of a functional single
nucleotide polymorphism (val108/158met) within the catechol-O-methyltransferase (COMT) …
(“noise”) has been associated with genetic risk for schizophrenia. On the basis of animal
experiments and computational models, we have predicted that this prefrontal “noise”
phenotype would be related to variation in prefrontal dopamine (DA) signaling, which itself
might be abnormal in schizophrenia. In the present study, the effect of a functional single
nucleotide polymorphism (val108/158met) within the catechol-O-methyltransferase (COMT) …