Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis
AM McIntosh, BJ Baig, J Hall, D Job, HC Whalley… - Biological …, 2007 - Elsevier
BACKGROUND: There is growing evidence that the gene catechol-O-methyltransferase
(COMT) is involved in the etiopathogenesis of schizophrenia. This study sought to clarify the
effects of the COMT Val158Met polymorphism on brain structure, function, and risk of
developing schizophrenia in a well-characterized cohort of individuals at high risk of
schizophrenia for familial reasons. METHODS: In a sample of 78 people at high genetic risk
of schizophrenia, the risk of progression to schizophrenia associated with the COMT Val …
(COMT) is involved in the etiopathogenesis of schizophrenia. This study sought to clarify the
effects of the COMT Val158Met polymorphism on brain structure, function, and risk of
developing schizophrenia in a well-characterized cohort of individuals at high risk of
schizophrenia for familial reasons. METHODS: In a sample of 78 people at high genetic risk
of schizophrenia, the risk of progression to schizophrenia associated with the COMT Val …