Association of AKT1 with schizophrenia confirmed in a Japanese population
M Ikeda, N Iwata, T Suzuki, T Kitajima, Y Yamanouchi… - Biological …, 2004 - Elsevier
BACKGROUND: Abnormality of the V-akt murine thymoma viral oncogene homologue 1
(AKT1) may be a predisposing factor in schizophrenia. Recent evidence supporting this
hypothesis showed decreased AKT1 protein levels in patients with schizophrenia and
significant association of AKT1 haplotypes according to the transmission disequilibrium test.
METHODS: We provide the first replication of this evidence using a relatively large case–
control sample (507 Japanese schizophrenia and 437 control subjects). We genotyped five …
(AKT1) may be a predisposing factor in schizophrenia. Recent evidence supporting this
hypothesis showed decreased AKT1 protein levels in patients with schizophrenia and
significant association of AKT1 haplotypes according to the transmission disequilibrium test.
METHODS: We provide the first replication of this evidence using a relatively large case–
control sample (507 Japanese schizophrenia and 437 control subjects). We genotyped five …