Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families
SG Schwab, B Hoefgen, C Hanses, MB Hassenbach… - Biological …, 2005 - Elsevier
BACKGROUND: Involvement of AKT signaling pathways in schizophrenia has been recently
suggested, on the basis of several lines of evidence. In addition to impairment of protein-
levels and phosphorylation levels in the pathway, association of DNA sequence variants in
the AKT1 gene with schizophrenia has been detected in a family sample. METHODS: We
investigated the reported association of DNA sequence variants in the AKT1 gene in a
sample of 79 sib-pair families with schizophrenia using the five single nucleotide …
suggested, on the basis of several lines of evidence. In addition to impairment of protein-
levels and phosphorylation levels in the pathway, association of DNA sequence variants in
the AKT1 gene with schizophrenia has been detected in a family sample. METHODS: We
investigated the reported association of DNA sequence variants in the AKT1 gene in a
sample of 79 sib-pair families with schizophrenia using the five single nucleotide …