[HTML][HTML] Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor γ agonists
AR Nawrocki, MW Rajala, E Tomas, UB Pajvani… - Journal of Biological …, 2006 - ASBMB
The adipose tissue-derived hormone adiponectin improves insulin sensitivity and its
circulating levels are decreased in obesity-induced insulin resistance. Here, we report the
generation of a mouse line with a genomic disruption of the adiponectin locus. We aimed to
identify whether these mice develop insulin resistance and which are the primary target
tissues affected in this model. Using euglycemic/insulin clamp studies, we demonstrate that
these mice display severe hepatic but not peripheral insulin resistance. Furthermore, we …
circulating levels are decreased in obesity-induced insulin resistance. Here, we report the
generation of a mouse line with a genomic disruption of the adiponectin locus. We aimed to
identify whether these mice develop insulin resistance and which are the primary target
tissues affected in this model. Using euglycemic/insulin clamp studies, we demonstrate that
these mice display severe hepatic but not peripheral insulin resistance. Furthermore, we …