Interleukin-6 polymorphisms, Helicobacter pylori infection in adult Brazilian patients with chronic gastritis and gastric adenocarcinoma
LL Gatti, RR Burbano, M Zambaldi-Tunes… - Archives of medical …, 2007 - Elsevier
BACKGROUND: The discovery of Helicobacter pylori offered the etiologic agent of the
initiating event of the inflammatory cascade. It has been confirmed that the development of
gastric cancer spans over several decades sequentially starting with the acquisition of H.
pylori infection and the development of chronic gastritis. The IL-6 gene (Il-6), inflammatory
cytokine and the single-nucleotide polymorphisms (SNPs) at the 5′ flanking region of the Il-
6 gene promoter (G or C at− 174 base and at− 572 or− 597 C or A) have been identified with …
initiating event of the inflammatory cascade. It has been confirmed that the development of
gastric cancer spans over several decades sequentially starting with the acquisition of H.
pylori infection and the development of chronic gastritis. The IL-6 gene (Il-6), inflammatory
cytokine and the single-nucleotide polymorphisms (SNPs) at the 5′ flanking region of the Il-
6 gene promoter (G or C at− 174 base and at− 572 or− 597 C or A) have been identified with …