A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors
DA Schaumberg, SE Hankinson, Q Guo… - Archives of …, 2007 - jamanetwork.com
Objectives To delineate the magnitude of susceptibility to age-related macular degeneration
(AMD) due to common variants in the gene for complement factor H (CFH) and the predicted
geneLOC387715and to determine whether these variants interact with modifiable risk
factors. Methods We compared cases who developed AMD (n= 457) with 1071 age-and sex-
matched control subjects in a prospective nested case-control study within the Nurses'
Health Study and the Health Professionals Follow-up Study. We determined the incidence …
(AMD) due to common variants in the gene for complement factor H (CFH) and the predicted
geneLOC387715and to determine whether these variants interact with modifiable risk
factors. Methods We compared cases who developed AMD (n= 457) with 1071 age-and sex-
matched control subjects in a prospective nested case-control study within the Nurses'
Health Study and the Health Professionals Follow-up Study. We determined the incidence …