A blast from the past: clearance of apoptotic cells regulates immune responses
J Savill, I Dransfield, C Gregory, C Haslett - Nature Reviews …, 2002 - nature.com
J Savill, I Dransfield, C Gregory, C Haslett
Nature Reviews Immunology, 2002•nature.comApoptosis, which is a programmed and physiological form of cell death, is known to shape
the immune system by regulating populations of effector lymphocytes. However, the binding
and ingestion of dying cells by monocytes/macrophages and dendritic cells can also
influence immune responses markedly by enhancing or suppressing inflammation.
Therefore, dead cells, which are a reflection of an organism's immediate past, can control its
immunological future.
the immune system by regulating populations of effector lymphocytes. However, the binding
and ingestion of dying cells by monocytes/macrophages and dendritic cells can also
influence immune responses markedly by enhancing or suppressing inflammation.
Therefore, dead cells, which are a reflection of an organism's immediate past, can control its
immunological future.
Abstract
Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation. Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future.
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