Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma
WK Han, A Alinani, CL Wu, D Michaelson… - Journal of the …, 2005 - journals.lww.com
Human kidney injury molecule-1 (hKIM-1) is a type 1 transmembrane protein that is not
detectable in normal kidney tissue but is expressed at high levels in human and rodent
kidneys with dedifferentiated proximal tubule epithelial cells after ischemic or toxic injury.
Therefore, it was hypothesized that renal tumors express hKIM-1 and release this protein
into the urine. Forty renal cell carcinoma (RCC) and 484 nonrenal tumors were analyzed by
immunohistochemistry for expression of hKIM-1 (group 1). Urine samples before …
detectable in normal kidney tissue but is expressed at high levels in human and rodent
kidneys with dedifferentiated proximal tubule epithelial cells after ischemic or toxic injury.
Therefore, it was hypothesized that renal tumors express hKIM-1 and release this protein
into the urine. Forty renal cell carcinoma (RCC) and 484 nonrenal tumors were analyzed by
immunohistochemistry for expression of hKIM-1 (group 1). Urine samples before …