Accelerated antigen presentation and elicitation of humoral response in vivo by FcγRIIB-and FcγRI/III-mediated immune complex uptake
A Yada, S Ebihara, K Matsumura, S Endo, T Maeda… - Cellular …, 2003 - Elsevier
It is well established that activating-type Fc receptors for IgG (FcγR), such as FcγRI and
FcγRIII, are essential for inducing inflammatory responses, whereas a unique inhibitory
FcγR, FcγRIIB, inhibits intracellular signaling upon ligation of IgG-immune complexes, and
can suppress inflammation and autoimmunity. Although antigen presentation is a crucial
step for evoking inflammatory responses, the contribution of FcγRIIB to antigen presentation
is controversial as to whether it regulates antigen-presenting cells (APC), particularly …
FcγRIII, are essential for inducing inflammatory responses, whereas a unique inhibitory
FcγR, FcγRIIB, inhibits intracellular signaling upon ligation of IgG-immune complexes, and
can suppress inflammation and autoimmunity. Although antigen presentation is a crucial
step for evoking inflammatory responses, the contribution of FcγRIIB to antigen presentation
is controversial as to whether it regulates antigen-presenting cells (APC), particularly …