[HTML][HTML] N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR)
S Beharry, M Zhong, RS Molday - Journal of Biological Chemistry, 2004 - ASBMB
ABCA4, a member of the family of ATP binding cassette (ABC) proteins found in rod and
cone photoreceptors, has been implicated in the transport of retinoid compounds across the
outer segment disk membrane following the photoactivation of rhodopsin. Mutations in the
ABCA4 gene are responsible for Stargardt macular dystrophy and related retinal
degenerative diseases that cause a loss in vision. To identify the retinoid substrate that
interacts with ABCA4, we have isolated ABCA4 from rod outer segment disk membranes on …
cone photoreceptors, has been implicated in the transport of retinoid compounds across the
outer segment disk membrane following the photoactivation of rhodopsin. Mutations in the
ABCA4 gene are responsible for Stargardt macular dystrophy and related retinal
degenerative diseases that cause a loss in vision. To identify the retinoid substrate that
interacts with ABCA4, we have isolated ABCA4 from rod outer segment disk membranes on …